Prednisolone is a man-made steroid used to treat several conditions that cause inflammation. The list of conditions treated by this drug includes lupus, psoriasis, issues with the nervous system, blood cells, skin, eyes and sever others.

Conditions that Prednisolone Treats

  • Bouillaud’s disease, rheumatic chorea.
  • Connective tissue issues, namely systemic scleroderma, giant temporal arteritis, acute disseminated myositis.
  • Multiple sclerosis/MS.
  • Joint diseases, namely rheumatoid arthritis/RA, juvenile arthritis/JA, Struempell-Marie disease, psoriasis-related arthritis, polyarthritis, Duplay’s disease, degenerative arthritis, Still’s disease, bursitis, non-specific tenosynovitis with effusion, synovitis, epicondylitis.
  • Spasmodic asthma/status asthmaticus.
  • Diffuse parenchymal lung pathologies (acute pulmonary coccidioidomycosis, pulmonary fibrosis, Besnier-Boeck-Schaumann syndrome).
  • Lung cancer.
  • Chronic berillium disease, aspiration pneumonia.
  • Tuberculosis.
  • Addison’s disease.
  • Congenital adrenal hyperplasia.
  • Congenital adrenal cortical hyperplasia.
  • Acute nonsuppurative thyroiditis.
  • Allergic sicknesses, including food-related hyperresponsiveness, drug-related hyperresponsiveness, serum disease, grass pollen allergy, atopic eczema, dermatitis venenata, urticaria fever, allergic rhinitis, Quincke’s oedema, SJS, toxicodermatosis.
  • Hypoglycemic state.
  • Autoimmune diseases.
  • Pre-renal insufficiency.
  • Inflammatory bowel diseases, including non-specific ulcerative colitis, Crohn’s disease, enteronitis.
  • Blood diseases.
  • Skin diseases, including atopic dermatitis, psoriasis, eczema, irritant contact dermatitis, seborrheic dermatitis, pemphigus vulgaris.
  • Brain edema.
  • Eye issues, including both allergic and autoimmune (non-purulent keratitis, iridocyclitis, iritis, along with several others).
  • Bronchitis.
  • Neuroendocrine tumors of the prostate.
  • Transplant rejection.
  • Hypercalcaemia.

Please be aware of the fact that this list is not 100% exhaustive. There are many other sicknesses treated via the use of this pill.


Sick man with thermometer in mouth on bed
Use prednisolone to treat many conditions

1. Systematic approach. Pre-existing illnesses caused by bacteria, viruses, fungi and parasites: herpes simplex, herpes zoster, chicken pox, measles; amebiasis, Strongyloides infection; systemic fungal infection; active and passive tuberculosis. The exercise in severe germ-caused illnesses left with a specific therapy. Immunodeficiency disorders (namely Human immunodeficiency virus infection), adenopathy from Bacillus Calmette–Guérin injection; Gastroesophageal/digestive issues (incl. gastric ulcers, oesophagitis, gastritis, small bowel resection, diverticulitis); circulatory system illnesses, namely freshly-encountered heart attack, ADHF, high blood pressure (HBP), high level of lipids in blood; endocrine illnesses: diabetes mellitus (carbs intolerance as well), thyrotoxicosis/hypothyroidism, hyperadrenocorticism; chronic renal and/or hepatic failure, nephrolithiasis; hypoalbuminaemia; oral bone loss, myasthenia gravis, schizophrenia, excessive weight, open-angle and narrow-angle glaucoma, gestation.

2. Intraarticular injection. Pre-arthroplasty, intracranial haemorrhaging (endogenous or blood thinners use related), broken bones, systemic inflammatory response syndrome in the joints, general infectious illnesses, porous bone, substantial bone destruction and ankylosis, damaged joints because of arthritis, osteonecrosis of the joints, pregnancy.

3. Gel. Bacterial, viral, fungal skin illnesses, cutaneous manifestations of syphilis, cutaneous tuberculosis, skin cancers, acne, adult acne (can possibly lead to an even worse situation), gestation.

4. Eye drops. Viral and fungal eye conditions, acute purulent pinkeye, pyoderma of the mucosa of the eye/eyelids, ulcerative keratitis, viral pinkeye, trachoma, glaucoma, primary corneal dystrophy; ocular TB; recent corneal foreign body removal.

How to Use

Prednisolone is taken orally, together with food or milk in order to avoid stomach upset. You have to measure the dose carefully, utilizing a special measuring device. Never use a simple spoon, you might end up with an incorrect dosage.

There are many ways you can take Prednisolone, so the dosages vary greatly. You need to read the information provided by the manufacturer/follow your doctor’s exact instructions. You must also follow the dosage schedule carefully because it is based entirely on the specific condition you are treating.

Never stop taking this medication or alter the dosage without talking to your MD first. Some of the specified diseases may worsen if this treatment is abruptly stopped. Your MD may up or lower your dosage, based on the results.

You may suffer from withdrawal in cases you have been taking Prednisolone for an extended time period. Your health specialist will have to slowly reduce the dosage in order to avoid such situation.


Digestion-related: retention of Natrium and fluids in the body, hypokalaemia, increase in the pH of the blood, nitrogen imbalance caused by destructive metabolism, high blood sugar, glycosuria, increase in body mass.

Endocrine system-related: hypocortisolism, pituitary-hypothalamus insufficiency, Cushing’s disease; stunted growth in kids; menstruation cycle disruption; lowered tolerance to carbs; onset of latent autoimmune diabetes, a stronger need for insulin or exenatide, liraglutide and pramlintide in patients suffering from diabetes mellitus.

Blood and circulatory system-related: elevated BP, development of congestive heart failure, blood clotting, deep vein thrombosis, noticeable electrocardiography changes, obliterating arteritis.

Musculoskeletal system-related: myasthenia, negative glucocorticoid impact, sarcopenia-like symptoms, porous bone, spinal compression fracture, osteonecrosis of the femoral head and humerus bones, pathological fractures of tubular bones.

Gastrointestinal tract-related: steroid-induced ulcer with the possibility of bleeding, pancreatitis, having gas, erosive esophagitis, digestive illnesses, feeling sick, barfing, hyperphagia.

Skin-related: loss of skin color, subcutaneous and dermal atrophy, skin abscesses, atrophic striae, acne, slow wound healing, fragile skin, petechia and ecchymosis, redness of the skin or mucous membranes, hyperhidrosis.

Nervous system-related: mental illnesses including acute confusional state, euphoria, audio/visual hallucinations, depression; increased rise in pressure around the brain with Foster–Kennedy syndrome (pseudotumor cerebri – usually encountered in kids, symptoms including a headache, decreased visual acuity or double/blurry vision); somnipathy, lightheadedness, vertigo, visual impairments; sudden blindness, cortical cataracts, ocular Hypertension that can possibly impact the cranial nerve II, glaucoma; sudden bulging of the eye anteriorly out of the orbit.

Allergic reactions: both generalized (contact dermatitis, hives, anaphylaxis) and localized.

Miscellaneous: general fatigue, syncope, post-acute withdrawal syndrome.


The parallel usage of Prednisolone and digoxin and digitoxin because of hypokalaemia alleviates the risk of heart dysrhythmia. Barbiturates, AEDs (Phenobarbital, Primidone) and Rimactane boost the metabolism of steroid hormones (via microsomal enzymes introduction) and worsen their impact. Antihistamine pills hinder the action of Prednisolone. Water pills, amphotericin B, carbonic anhydrase inhibitors alleviate the risk of severe hypokalaemia, Na + -containing tablets alleviate the risk of serious BP issues.

When using both this tablet and acetaminophen, your risk of hepatic toxicity is bigger. OCPs containing estrogens can change this drug’s metabolism, reducing clearance/increasing half-life, and as a result – both therapeutic and toxic effects of this tablet are significantly boosted. Taking this drug together with blood thinners in all likelihood will lead to the latter’s effect getting seriously hindered. TCAs can possibly worsen the psychiatric issues closely related to the usage of this medication – the severity of depression, for example.

Prednisolone hinders the hypoglycemic impact of oral antihyperglycemic agents and insulin. Immunosuppressive medications alleviate the risk of infections and blood cancers that develop from lymphocytes. Nonsteroidal anti-inflammatory drugs, Aspirin, liquor – all alleviate the risk of encountering duodenal ulcer disease and gastrointestinal tract bleeding.

This list of possible interactions is not 100% exhaustive, you must consult your MD before you decide to undergo this You must provide them with the exhaustive list of all the things you are currently taking, including OTC pills, herbals, and prescription tablets.


  • The risk of an overdose comes from prolonged usage/incorrect doses.
  • Symptoms: upped BP, peripheral edema, severe unwanted effects of the drug.
  • Treatment of acute overdose: gastric irrigation or induced vomiting.
  • Treatment of chronic overdose: lowering the dosage.

How to Increase this Drug’s Efficiency?

There are several ways you can do that. First and foremost, you need to follow your MD’s exact orders. Do not alter the dosage, do not suddenly stop taking this tablet under any circumstances. As a general rule, you should probably consider making some beneficial lifestyle changes that can cure your condition in combination with this treatment. Here are a few examples of these lifestyle changes: losing extra weight, quitting smoking, curbing your alcohol intake, living a more active lifestyle, lessening the stress level and several others.

Miscellaneous Information

  • This tablet is typically taken as a short course.
  • There’s a generic version of this drug available on the market.
  • There’s a rare side-effect that happens only if you take this medicine in combination with anti-rejection drugs/steroids. You will suffer from anger-related issues/intermittent explosive disorder.
  • If you happen to accidentally skip a dose, you should contact your health specialist immediately.
  • It is one of the most effective drugs when it comes to treating inflammatory conditions.
Jack userpic

Had some hardcore itching, had some redness and rashes in between my toes. The doctor said it was something similar to contact dermatitis. Have been taking this drug for 5 days now. Even within the first 3 days, the itching disappeared completely, and rashes faded as well. I don’t know what the other people think of it and how great/not great their experiences were, but I think this drug is one of the most effective out there. I have encountered no side-effects whatsoever, by the way. Pretty neat, huh?

Evan userpic

Had a really stubborn infection that just won’t go away (8+ months). My doctor prescribed a week of 30mg. Prednisolone. The first few days I felt so-so, then I had this sudden burst of energy, clearer breathing, better sleep quality, etc. This drug also managed to somewhat cure my anxiety and panic for some reason. No more shaking, feeling weak-legged or anything like that. After five days of this treatment, my sinus problems were solved. I guess this is great drug. Strongly recommended to y’all.

Joe userpic

I had a really rough time with Pemphigoid/Pemphigus, nothing was helping at all. My doctor suggested Prednisolone, it was actually sitting in my cupboard for some time – I was scared of taking these pills, having read all kinds of horror stories about side-effects and whatnot. I know these drugs don’t really suit everyone, but they worked just fine for me. More than fine, actually – they worked excellent. There are some minor side-effects, such as night sweating and leg twitching, but it’s totally worth it.

Dylan userpic

This medication is THE BEST. I’m not kidding and here’s why. My asthma has been under control for almost seven years now. After I was introduced to Prednisolone, everything has changed for me. My life was back on track, it’s fantastic. True story: my friend had a severe (REAL severe) heat rash and I suggested Prednisolone, since it’s so great and all. It was actually able to clear it up WITHIN DAYS. So, in short, Prednisolone is awesome. Thank you, Prednisolone, both from me and my friend, hahaha.